Mouse Heyl activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Heyl
Locus ID	56198
Kit Components	GA205855G1, Heyl gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205855G2, Heyl gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205855G3, Heyl gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_013905
Synonyms	bHLHb33; hesr3; Hey3; Hrt3
Summary	Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.[UniProtKB/Swiss-Prot Function]

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