Mouse Il36rn activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il36rn
Locus ID	54450
Kit Components	GA205715G1, Il36rn gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205715G2, Il36rn gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205715G3, Il36rn gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001146087, NM_001146088, NM_019451
Synonyms	AI413231; Fil1delta; Il-1h3; IL-36Ra; Il1hy1; IL36RN
Summary	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.[UniProtKB/Swiss-Prot Function]

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