Mouse Arhgef25 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Arhgef25
Locus ID	52666
Kit Components	GA205502G1, Arhgef25 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205502G2, Arhgef25 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205502G3, Arhgef25 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001166413, NM_028027, NM_001358557, NM_001358558
Synonyms	2410008H17Rik; D10Ertd610e; GEFT
Summary	May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.[UniProtKB/Swiss-Prot Function]

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