Mouse Rcn3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rcn3
Locus ID	52377
Kit Components	GA205466G1, Rcn3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205466G2, Rcn3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205466G3, Rcn3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_026555, NM_001355045
Synonyms	6030455P07Rik; D7Ertd671e; D530026G20Rik; RLP49
Summary	Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:26252542). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (PubMed:26252542). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (PubMed:26252542). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity).[UniProtKB/Swiss-Prot Function]

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