Mouse Atxn1l activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atxn1l
Locus ID	52335
Kit Components	GA205462G1, Atxn1l gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205462G2, Atxn1l gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205462G3, Atxn1l gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001080930, NM_001368350, NM_001368351, NM_001368352
Synonyms	AW558552; Boat; C330011L24Rik; D6Mgi37; D8Ertd587e; ENSMUSG00000069895
Summary	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (PubMed:16121196). In concert with CIC and ATXN1, involved in brain development (PubMed:28288114).[UniProtKB/Swiss-Prot Function]

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