Mouse Srrm1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Srrm1
Locus ID	51796
Kit Components	GA205418G1, Srrm1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205418G2, Srrm1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205418G3, Srrm1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001130477, NM_016799, NM_001369067, NM_001369068, NM_001369069, NM_001369070, NM_001369071, NM_001369072, NM_001369073, NM_001369074
Synonyms	AA407769; POP101; Srm160
Summary	Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.[UniProtKB/Swiss-Prot Function]

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