Mouse Keap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Keap1
Locus ID	50868
Kit Components	GA205381G1, Keap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205381G2, Keap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205381G3, Keap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001110305, NM_001110306, NM_001110307, NM_016679
Synonyms	INRF2; mKIAA0132
Summary	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).[UniProtKB/Swiss-Prot Function]

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