Mouse Cngb3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cngb3
Locus ID	30952
Kit Components	GA205303G1, Cngb3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205303G2, Cngb3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205303G3, Cngb3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_013927
Synonyms	CCNC2; CNG6; Cngbeta2
Summary	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3.[UniProtKB/Swiss-Prot Function]

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