Mouse Usp21 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Usp21
Locus ID	30941
Kit Components	GA205295G1, Usp21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205295G2, Usp21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205295G3, Usp21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_013919
Synonyms	ESTM28; Usp16; Usp23; W53272
Summary	Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization (By similarity).[UniProtKB/Swiss-Prot Function]

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