Mouse Zbtb18 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zbtb18
Locus ID	30928
Kit Components	GA205284G1, Zbtb18 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205284G2, Zbtb18 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205284G3, Zbtb18 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001012330, NM_013915, NM_001355098, NM_001355099, NM_001355100, NM_001355101, NM_001355102, NM_001355103
Synonyms	RP58; Zfp238; Znf238
Summary	Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus.[UniProtKB/Swiss-Prot Function]

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