Mouse Foxe3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Foxe3
Locus ID	30923
Kit Components	GA205279G1, Foxe3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205279G2, Foxe3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205279G3, Foxe3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_015758
Synonyms	dyl; FREAC8; rct
Summary	Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278). Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).[UniProtKB/Swiss-Prot Function]

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