Mouse Fbxl12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxl12
Locus ID	30843
Kit Components	GA205275G1, Fbxl12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205275G2, Fbxl12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205275G3, Fbxl12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002846, NM_001286529, NM_001286530, NM_013911
Synonyms	3110048D16Rik; Fbl12
Summary	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity).[UniProtKB/Swiss-Prot Function]

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