Mouse Iqgap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Iqgap1
Locus ID	29875
Kit Components	GA205250G1, Iqgap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205250G2, Iqgap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205250G3, Iqgap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_016721
Synonyms	AA682088; D7Ertd237e; D7Ertd257e; mKIAA0051
Summary	Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.[UniProtKB/Swiss-Prot Function]

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