Mouse Cadps activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cadps
Locus ID	27062
Kit Components	GA205087G1, Cadps gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205087G2, Cadps gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205087G3, Cadps gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042617, NM_012061, NM_001359919, NM_001359920, NM_001359921
Synonyms	AU067781; CAPS; CAPS1; mKIAA1121
Summary	Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).[UniProtKB/Swiss-Prot Function]

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