Mouse Nit1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nit1
Locus ID	27045
Kit Components	GA205073G1, Nit1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205073G2, Nit1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205073G3, Nit1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001242580, NM_012049, NR_033728
Synonyms	AI255805; ESTM30; W57327
Summary	Catalyzes the hydrolysation of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.[UniProtKB/Swiss-Prot Function]

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