Mouse Orc4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Orc4
Locus ID	26428
Kit Components	GA204970G1, Orc4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204970G2, Orc4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204970G3, Orc4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177313, NM_011958, NR_033442, NR_149355, NR_149356, NM_001355296
Synonyms	mMmORC4; Orc4l; Orc4P
Summary	Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.[UniProtKB/Swiss-Prot Function]

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