Mouse Scn11a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scn11a
Locus ID	24046
Kit Components	GA204870G1, Scn11a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204870G2, Scn11a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204870G3, Scn11a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011887
Synonyms	NaN; NaT; NaV1.9; NSS2; SNS2
Summary	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity).[UniProtKB/Swiss-Prot Function]

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