Mouse Rgs7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rgs7
Locus ID	24012
Kit Components	GA204861G1, Rgs7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204861G2, Rgs7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204861G3, Rgs7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001199003, NM_001347195, NM_011880, NM_001357129
Summary	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.[UniProtKB/Swiss-Prot Function]

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