Mouse Papss2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Papss2
Locus ID	23972
Kit Components	GA204846G1, Papss2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204846G2, Papss2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204846G3, Papss2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001201470, NM_011864, NM_001360403
Synonyms	1810018P12Rik; AI159688; Atpsk2; AtpsU2; bm; Sk2
Summary	Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth.[UniProtKB/Swiss-Prot Function]

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