Mouse Ly6h activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ly6h
Locus ID	23934
Kit Components	GA204820G1, Ly6h gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204820G2, Ly6h gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204820G3, Ly6h gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135688, NM_001135689, NM_011837
Summary	Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394). May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface (PubMed:25716842). Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity).[UniProtKB/Swiss-Prot Function]

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