Mouse Hs2st1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hs2st1
Locus ID	23908
Kit Components	GA204807G1, Hs2st1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204807G2, Hs2st1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204807G3, Hs2st1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011828, NM_001355234
Synonyms	AW214369; Hs2st; mKIAA0448
Summary	Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues.[UniProtKB/Swiss-Prot Function]

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