Mouse Eif4h activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Eif4h
Locus ID	22384
Kit Components	GA204622G1, Eif4h gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204622G2, Eif4h gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204622G3, Eif4h gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_033561
Synonyms	AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H; Wbscr1; Wscr1
Summary	This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

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