Mouse Vrk1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vrk1
Locus ID	22367
Kit Components	GA204611G1, Vrk1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204611G2, Vrk1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204611G3, Vrk1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001029843, NM_001029844, NM_011705, NM_001364365, NM_001364367, NM_001364368
Synonyms	51PK
Summary	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity).[UniProtKB/Swiss-Prot Function]

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