Mouse Uros activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Uros
Locus ID	22276
Kit Components	GA204559G1, Uros gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204559G2, Uros gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204559G3, Uros gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001302085, NM_001302086, NM_001302087, NM_009479, NR_153415, NR_153416
Synonyms	AI415298; UROIIIS; Uros3
Summary	The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

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