Mouse Tsg101 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tsg101
Locus ID	22088
Kit Components	GA204464G1, Tsg101 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204464G2, Tsg101 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204464G3, Tsg101 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_021884, NM_001348088, NM_001348089
Synonyms	AI255943; CC2
Summary	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).[UniProtKB/Swiss-Prot Function]

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