Mouse Tpmt activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tpmt
Locus ID	22017
Kit Components	GA204426G1, Tpmt gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204426G2, Tpmt gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204426G3, Tpmt gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_016785
Synonyms	AW106912
Summary	Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.[UniProtKB/Swiss-Prot Function]

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