Mouse Tnp1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tnp1
Locus ID	21958
Kit Components	GA204409G1, Tnp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204409G2, Tnp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204409G3, Tnp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009407
Synonyms	Stp-1; Tp-1; TP1
Summary	Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AFB1-HIST1H2BA/TH2B dimer is required for loading of TNP1 onto chromatin (PubMed:28366643).[UniProtKB/Swiss-Prot Function]

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