Mouse Tnfrsf10b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tnfrsf10b
Locus ID	21933
Kit Components	GA204389G1, Tnfrsf10b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204389G2, Tnfrsf10b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204389G3, Tnfrsf10b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020275
Synonyms	DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB
Summary	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[UniProtKB/Swiss-Prot Function]

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