Mouse Klf10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Klf10
Locus ID	21847
Kit Components	GA204348G1, Klf10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204348G2, Klf10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204348G3, Klf10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289471, NM_013692, NM_001357677
Synonyms	AI115143; Egral; EGR[a]; Gdnfif; mGIF; Tieg; TIEG-1; Tieg1
Summary	Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis.[UniProtKB/Swiss-Prot Function]

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