Mouse Tgm3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tgm3
Locus ID	21818
Kit Components	GA204328G1, Tgm3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204328G2, Tgm3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204328G3, Tgm3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009374
Synonyms	AI893889; TG(E); TGase-3; TGase E; TG E; TGE; we
Summary	Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.[UniProtKB/Swiss-Prot Function]

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