Mouse Kdm5c activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kdm5c
Locus ID	20591
Kit Components	GA203983G1, Kdm5c gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203983G2, Kdm5c gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203983G3, Kdm5c gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_013668
Synonyms	D930009K15Rik; Jarid1c; mKIAA0234; Smcx
Summary	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.[UniProtKB/Swiss-Prot Function]

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