Mouse Slc8a1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Slc8a1
Locus ID	20541
Kit Components	GA203967G1, Slc8a1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203967G2, Slc8a1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203967G3, Slc8a1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001112798, NM_001286684, NM_011406, NR_104580
Synonyms	AI852629; AV344025; D930008O12Rik; Ncx1
Summary	Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8659820). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:10967099). Required for normal embryonic heart development and the onset of heart contractions (PubMed:10967099).[UniProtKB/Swiss-Prot Function]

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