Mouse Sin3b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sin3b
Locus ID	20467
Kit Components	GA203910G1, Sin3b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203910G2, Sin3b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203910G3, Sin3b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001113248, NM_009188
Synonyms	2810430C10Rik
Summary	Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904).[UniProtKB/Swiss-Prot Function]

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