Mouse Scn9a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scn9a
Locus ID	20274
Kit Components	GA203786G1, Scn9a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203786G2, Scn9a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203786G3, Scn9a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001290674, NM_001290675, NM_018852
Synonyms	mKIAA4197; Nav1.7; PN1
Summary	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:15123669). It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:15314237).[UniProtKB/Swiss-Prot Function]

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