Mouse Scn3a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scn3a
Locus ID	20269
Kit Components	GA203782G1, Scn3a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203782G2, Scn3a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203782G3, Scn3a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_018732, NM_001355166, NM_001355167, NM_001355168, NM_001355169, NM_001355170, NM_001355171
Synonyms	Gm1000; Nav1.3
Summary	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:29142310). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (PubMed:29142310). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (PubMed:25172946).[UniProtKB/Swiss-Prot Function]

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