Mouse Atxn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atxn1
Locus ID	20238
Kit Components	GA203770G1, Atxn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203770G2, Atxn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203770G3, Atxn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001199304, NM_001199305, NM_009124
Synonyms	2900016G23Rik; Atx1; C85907; ENSMUSG00000074917; Gm10786; Sca1
Summary	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). May be involved in RNA metabolism (By similarity). In concert with CIC and ATXN1L, involved in brain development (PubMed:28288114).[UniProtKB/Swiss-Prot Function]

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