Mouse Ryr2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ryr2
Locus ID	20191
Kit Components	GA203741G1, Ryr2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203741G2, Ryr2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203741G3, Ryr2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023868
Synonyms	9330127I20Rik; RYR-2
Summary	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.[UniProtKB/Swiss-Prot Function]

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