Mouse Polr1b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Polr1b
Locus ID	20017
Kit Components	GA203699G1, Polr1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203699G2, Polr1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203699G3, Polr1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_009086
Synonyms	128kDa; D630020H17Rik; RPA2; RPA116; RPA135; Rpo1-2
Summary	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).[UniProtKB/Swiss-Prot Function]

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