Mouse Rbpms activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rbpms
Locus ID	19663
Kit Components	GA203593G1, Rbpms gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203593G2, Rbpms gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203593G3, Rbpms gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042674, NM_001042675, NM_001286168, NM_019733
Synonyms	2010300K22Rik; 2700019M19Rik; AU017537; hermes; RBP-MS
Summary	Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.[UniProtKB/Swiss-Prot Function]

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