Mouse Ptpra activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptpra
Locus ID	19262
Kit Components	GA203484G1, Ptpra gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203484G2, Ptpra gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203484G3, Ptpra gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163688, NM_008980, NM_001355161
Synonyms	Ptpa; Ptpalpha; Rptpalpha; Rptra; Rptralpha
Summary	Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (PubMed:22801373). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (PubMed:22801373).[UniProtKB/Swiss-Prot Function]

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