Mouse Ptch1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptch1
Locus ID	19206
Kit Components	GA203442G1, Ptch1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203442G2, Ptch1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203442G3, Ptch1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001328514, NM_008957
Synonyms	A230106A15Rik; mes; Ptc; Ptc1; Ptch
Summary	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.[UniProtKB/Swiss-Prot Function]

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