Mouse Ppm1a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ppm1a
Locus ID	19042
Kit Components	GA203351G1, Ppm1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203351G2, Ppm1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203351G3, Ppm1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008910
Synonyms	2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1
Summary	Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.[UniProtKB/Swiss-Prot Function]

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