Mouse Plxna1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Plxna1
Locus ID	18844
Kit Components	GA203299G1, Plxna1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203299G2, Plxna1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203299G3, Plxna1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008881
Synonyms	2600013D04Rik; mKIAA4053; NOV; PlexA1; Plxn1
Summary	Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.[UniProtKB/Swiss-Prot Function]

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