Mouse Plaa activation kit by CRISPRa
CAT#: GA203269
Plaa CRISPRa kit - CRISPR gene activation of mouse phospholipase A2, activating protein
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Plaa |
Locus ID | 18786 |
Kit Components | GA203269G1, Plaa gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203269G2, Plaa gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203269G3, Plaa gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_172695 |
Synonyms | 2410007N06; AI536418; AU018445; AW208417; D4Ertd618e; PLA2P; PLAP; Ufd3 |
Summary | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (PubMed:28413018). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:28007986).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN513398 | Plaa - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |