Mouse Pkm activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pkm
Locus ID	18746
Kit Components	GA203238G1, Pkm gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203238G2, Pkm gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203238G3, Pkm gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001253883, NM_011099
Synonyms	AA414905; AL024370; AL024424; Pk-2; Pk-3; Pk3; Pkm2
Summary	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (PubMed:29996098).[UniProtKB/Swiss-Prot Function]

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