Mouse Pikfyve activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pikfyve
Locus ID	18711
Kit Components	GA203220G1, Pikfyve gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203220G2, Pikfyve gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203220G3, Pikfyve gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310624, NM_011086
Synonyms	5230400C17Rik; p235; Pip5k; Pip5k3; Pipk5k3; PipkIII
Summary	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole.[UniProtKB/Swiss-Prot Function]

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