Mouse Pfn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pfn1
Locus ID	18643
Kit Components	GA203190G1, Pfn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203190G2, Pfn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203190G3, Pfn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011072
Synonyms	Pfn
Summary	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).[UniProtKB/Swiss-Prot Function]

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