Mouse Pde8a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pde8a
Locus ID	18584
Kit Components	GA203149G1, Pde8a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203149G2, Pde8a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203149G3, Pde8a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_008803
Synonyms	AI551852; Pde8
Summary	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.[UniProtKB/Swiss-Prot Function]

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