Mouse Pdcd4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pdcd4
Locus ID	18569
Kit Components	GA203137G1, Pdcd4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203137G2, Pdcd4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203137G3, Pdcd4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001168491, NM_001168492, NM_011050
Synonyms	D19Ucla1; Ma3; Tis
Summary	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.[UniProtKB/Swiss-Prot Function]

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