Mouse Furin activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Furin
Locus ID	18550
Kit Components	GA203126G1, Furin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203126G2, Furin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203126G3, Furin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081454, NM_011046
Synonyms	9130404I01Rik; Fur; PACE; Pcsk3; SPC1
Summary	This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

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